Visiting Scientist from St George's, University of London at the IAI
- Source: IAI
- Date: 2022-04-21, updated 2022-04-27
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Kai Hilpert is a guest scientist visiting the ML4TIME group. He is an associate Professor from St George's, University of London. For many years he has been developing new antimicrobial compounds (peptides) against multi-drug resistant pathogenic bacteria. In a new study from 2022, it was reported that in 2019 about 1.27 million people died as a consequence of infections caused by resistant bacteria and 4.95 million deaths were associated with antimicrobial resistance. These numbers show the dimensions of the burden caused by infectious microorganisms where no treatment is available. In addition, other medical procedures like operations, transplantations, and chemotherapy would be not possible or at very high risk in case no antibiotics are effective anymore. Antimicrobial resistance is an ongoing problem that intensified with a loss of investment and interest in most larger pharma companies in the last decades. Consequently, a gap in antimicrobial drug development appeared, for nearly 40 years no new structural class was developed. Kai Hilpert and Ralf Mikut will work on the analysis of screening data for antimicrobial activity and toxicity to identify and understand novel antimicrobials synthesized in the group of Kai Hilpert. His stay will last until early June 2022.
Publications
Hilpert, K.; Rumancev, C.; Gani, J.; Collis, D. W. P.; Lopez-Perez, P. M.; Garamus, V. M.; Mikut, R.; Rosenhahn, A.
2023. Frontiers in Pharmacology, 14, Art.-Nr.: 1141785. doi:10.3389/fphar.2023.1141785
Oyama, L. B.; Olleik, H.; Teixeira, A. C. N.; Guidini, M. M.; Pickup, J. A.; Hui, B. Y. P.; Vidal, N.; Cookson, A. R.; Vallin, H.; Wilkinson, T.; Bazzolli, D. M. S.; Richards, J.; Wootton, M.; Mikut, R.; Hilpert, K.; Maresca, M.; Perrier, J.; Hess, M.; Mantovani, H. C.; Fernandez-Fuentes, N.; Creevey, C. J.; Huws, S. A.
2022. npj Biofilms and Microbiomes, 8 (1), Artikel-Nr.: 58. doi:10.1038/s41522-022-00320-0
Hilpert, K.; Gani, J.; Rumancev, C.; Simpson, N.; Lopez-Perez, P. M.; Garamus, V. M.; Gundlach, A. R. von; Markov, P.; Scocchi, M.; Mikut, R.; Rosenhahn, A.
2021. Frontiers in pharmacology, 12, Article no: 769739. doi:10.3389/fphar.2021.769739
Hilpert, K.; Mikut, R.
2021. Frontiers in Microbiology, 12, Art.-Nr.: 732838. doi:10.3389/fmicb.2021.732838
Grimsey, E.; Collis, D. W. P.; Mikut, R.; Hilpert, K.
2020. Biochimica et biophysica acta / Biomembranes, 1862 (8), Art.Nr.: 183195. doi:10.1016/j.bbamem.2020.183195
Ruden, S.; Rieder, A.; Chis Ster, I.; Schwartz, T.; Mikut, R.; Hilpert, K.
2019. Frontiers in microbiology, 10, Art. Nr.: 2740. doi:10.3389/fmicb.2019.02740
Gundlach, A. von; Ashby, M. P.; Gani, J.; Lopez-Perez, P. M.; Cookson, A. R.; Ann Huws, S.; Rumancev, C.; Garamus, V. M.; Mikut, R.; Rosenhahn, A.; Hilpert, K.
2019. Frontiers in pharmacology, 10, Art. Nr.: 1127. doi:10.3389/fphar.2019.01127
Oyama, L. B.; Olleik, H.; Nery Teixeira, A. C.; Guidini, M. M.; Maresca, M.; Bazzolli, D.; Cookson, A. C.; Fuentes, N. F.; Vallin, H.; Pickup, J.; Mikut, R.; Hilpert, K.; Richards, J.; Wootton, M.; Edwards, J. E.; Perrier, J.; Hess, M.; Mantovani, H. C.; Creevey, C. J.; Huws, S. A.
2019. Gordon Research Conference - Antimicrobial Peptides: Mechanisms and Application: Realizing the Potential of Antimicrobial Host Defense Peptides for Human and Veterinary Medicine (GRC 2019), Lucca, Italy, February 24–March 1, 2019
Oyama, L. B.; Olleik, H.; Nery Teixeira, A. C.; Guidini, M. M.; Pickup, J. A.; Cookson, A. R.; Vallin, H.; Wilkinson, T.; Bazzolli, D.; Richards, J.; Wootton, M.; Mikut, R.; Hilpert, K.; Maresca, M.; Perrier, J.; Hess, M.; Mantovani, H. C.; Fernandez-Fuentes, N.; Creevey, C. J.; Huws, S. A.
2019. bioRxiv beta, 42 S. doi:10.1101/577221
Oyama, L. B.; Girdwood, S. E.; Cookson, A. R.; Fernandez-Fuentes, N.; Privé, F.; Vallin, H. E.; Wilkinson, T. J.; Golyshin, P. N.; Golyshina, O. V.; Mikut, R.; Hilpert, K.; Richards, J.; Wootton, M.; Edwards, J. E.; Maresca, M.; Perrier, J.; Lundy, F. T.; Luo, Y.; Zhou, M.; Hess, M.; Mantovani, H. C.; Creevey, C. J.; Huws, S. A.
2017. npj Biofilms and Microbiomes, 3 (1), Art.Nr. 33. doi:10.1038/s41522-017-0042-1
López-Pérez, P. M.; Grimsey, E.; Bourne, L.; Mikut, R.; Hilpert, K.
2017. Frontiers in Chemistry, 5, Article 25. doi:10.3389/fchem.2017.00025
Ashby, M.; Petkova, A.; Gani, J.; Mikut, R.; Hilpert, K.
2017. Current topics in medicinal chemistry, 17 (5), 537–553. doi:10.2174/1568026616666160713125555
Oyama, L. B.; Girdwood, S. E.; Cookson, A.; Fernandez-Fuentes, N.; Edwards, J. E.; Golyshin, P.; Golyshina, O.; Prive, F.; Mikut, R.; Hilpert, K.; Creevey, C. J.; Huws, S. A.
2016. INRA-ROWETT 2016, Gut Microbiology Symposium, Clemont, F, June 20-23, 2016
Oyama, L. B.; Girdwood, S. E.; Cookson, A.; Fernandez-Fuentes, N.; Prive, F.; Edwards, J. E.; Golyshin, P.; Golyshina, O.; Mikut, R.; Hilpert, K.; Hess, M.; Creeveyand, C.; Huws, S. A.
2016. New Antibacterial Discovery and Development : Gordon-Kenan Research Seminar, Lucca, I, March 12-13, 2016
Gundlach, A. R. von; Garamus, V. M.; Gorniak, T.; Davies, H. A.; Reischl, M.; Mikut, R.; Hilpert, K.; Rosenhahn, A.
2016. Biochimica et Biophysica Acta - Biomembranes, 1858 (5), 918–925. doi:10.1016/j.bbamem.2015.12.022
Mikut, R.; Ruden, S.; Reischl, M.; Breitling, F.; Volkmer, R.; Hilpert, K.
2016. Biochimica et Biophysica Acta - Biomembranes, 1858 (5), 1024–1033. doi:10.1016/j.bbamem.2015.12.013
Knappe, D.; Ruden, S.; Langanke, S.; Tikkoo, T.; Ritzer, J.; Mikut, R.; Martin, L. L.; Hoffmann, R.; Hilpert, K.
2016. Amino Acids, 48 (1), 269–280. doi:10.1007/s00726-015-2082-2
Oyama, L. B.; Girdwood, S. E.; Cookson, A.; Fernandez-Fuentes, N.; Edwards, J. E.; Golyshin, P.; Golyshina, O.; Prive, F.; Mikut, R.; Hilpert, K.; Creevey, C.; Huws, S. A.
2015. 5th International Meeting on Antimicrobial Peptides (IMAP 2015), London, GB, September 7-8, 2015
Yu, K.; Lai, B. F. L.; Gani, J.; Mikut, R.; Hilpert, K.; Kizhakkedathu, J. N.
2015. Biomaterials, 69, 201–211. doi:10.1016/j.biomaterials.2015.08.003
Ruden, S.; Gani, J.; Ashby, M.; Mikut, R.; Hilpert, K.
2014. 4th International Meeting on Antimicrobial Peptides (IMAP 2014), Graz, A, September 29-30, 2014
Ramon-Garcia, S.; Mikut, R.; Ng, C.; Ruden, S.; Volkmer, R.; Reischl, M.; Hilpert, K.; Thompson, C. J.
2013. Antimicrobial Agents and Chemotherapy, 57, 2295–2303. doi:10.1128/AAC.00175-13
Hilpert, K.; Ruden, S.; Hancock, R.; Mikut, R.
2010. MipTec Drug Discovery Conf.and Exhibition, Basel, CH, September 20-24, 2010 Journal of Peptide Science, 16(2010) Suppl.1, (Abstract)
Mikut, R.; Hilpert, K.
2010. Advances in Biomedical Research : Proc.of the 7th WSEAS Internat.Conf.on Mathematical Biology and Ecology (MABE’10), the Internat.Conf.on Medical Physiology (PHYSIOLOGY’10) and the Internat.Conf.on Biochemistry and Medical Chemistry (BIOMEDCH’10), Cambridge, GB, February 23-25, 2010 WSEAS Press, 2010 (Recent Advances in Biology and Biomedicine)
Mikut, R.; Hilpert, K.
2010. Advances in Biomedical Research : Proc.of the 7th WSEAS Internat.Conf.on Mathematical Biology and Ecology (MABE’10), the Internat.Conf.on Medical Physiology (PHYSIOLOGY’10) and the Internat.Conf.on Biochemistry and Medical Chemistry (BIOMEDCH’10), Cambridge, GB, February 23-25, 2010 WSEAS Press, 2010 (Recent Advances in Biology and Biomedicine), 327–29
Ruden, S.; Hilpert, K.; Mikut, R.; Ulrich, A. S.
2009. CFN Summer School on Nano-Biology, Bad Herrenalb, September 8-11, 2009
Hilpert, K.; Mikut, R.
2009. Vortr.: Universität Leipzig, 24.Juni 2009
Mikut, R.; Hilpert, K.
2009. International Journal of Peptide Research and Therapeutics, 15, 129–37. doi:10.1007/s10989-009-9172-5
Mikut, R.; Reischl, M.; Ulrich, A. S.; Hilpert, K.
2008. Mikut, R. [Hrsg.] Proc.18.Workshop Computational Intelligence, Dortmund, 3.-5.Dezember 2008 Karlsruhe : Universitätsverl.Karlsruhe, 2008 (Schriftenreihe des Instituts für Angewandte Informatik/Automatisierungstechnik Universität Karlsruhe (TH) ; Bd.24)
Mikut, R.; Reischl, M.; Ulrich, A. S.; Hilpert, K.
2008. Proceedings. 18. Workshop Computational Intelligence, Dortmund, 3.-5. Dezember 2008. Hrsg.: R. Mikut, 189–203, Universitätsverlag Karlsruhe